Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation.In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non-degradative ubiquitination modulates protein structure, dynamics, and function.Due to the wealth
Flip-flops may change walking gait pattern, increase muscle activity and joint loading, and predispose wearers to foot problems, despite that quantitative evidence is scarce.The purpose of this study was to examine the lower limb muscle co-contraction and joint contact force in flip-flops gait, and compare with those of barefoot and sports shoes wa
Gliomas are mostly incurable secondary to their diffuse infiltrative nature.Thus, specific therapeutic targeting of invasive glioma cells is an attractive concept.As cells exit the tumor mass and infiltrate brain parenchyma, they closely interact with a changing micro-environmental landscape that sustains tumor cell invasion.In this study, we used